Category Archives: research
Thrombin in complex with dabigatran can still interact with PAR-1 via exosite-I and instigate loss of vascular integrity.
Dólleman SC, Agten SM, Spronk HMH, Hackeng TM, Bos MHA, Versteeg HH, van Zonneveld AJ, de Boer HC. J Thromb Haemost. 2022 Apr;20(4):996-1007. PMID: 35037739 Background: Atrial fibrillation (AF) can lead to the loss of microvascular integrity thereby enhancing AF … Continue reading
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Effect of combining aspirin and rivaroxaban on atherosclerosis in mice.
Grover SP, Coughlin T, Fleifil SM, Posma JJN, Spronk HHM, Heitmeier S, Owens AP 3rd, Mackman N. Atherosclerosis. 2022 Mar;345:7-14. PMID: 35183904 Background and aims: The platelet inhibitor aspirin reduces inflammation and atherosclerosis in both apolipoprotein E deficient (apoE-/-) mice … Continue reading
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Protein C or Protein S deficiency associates with paradoxically impaired platelet-dependent thrombus and fibrin formation under flow.
Brouns SLN, Tullemans BME, Bulato C, Perrella G, Campello E, Spiezia L, van Geffen JP, Kuijpers MJE, van Oerle R, Spronk HMH, van der Meijden PEJ, Simioni P, Heemskerk JWM. Res Pract Thromb Haemost. 2022 Mar 7;6(2):e12678. PMID: 35284776 Background: … Continue reading
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The Composition and Physical Properties of Clots in COVID-19 Pathology.
Dauwerse S, Ten Cate H, Spronk HMH, Nagy M. Diagnostics (Basel). 2022 Feb 24;12(3):580. PMID: 35328132 Hemostasis is a finely tuned process of which dysregulation can lead either to bleeding or thrombotic complications. The latter is often caused by the … Continue reading
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Sustained inflammation, coagulation activation and elevated endothelin-1 levels without macrovascular dysfunction at 3 months after COVID-19.
Willems LH, Nagy M, Ten Cate H, Spronk HMH, Groh LA, Leentjens J, Janssen NAF, Netea MG, Thijssen DHJ, Hannink G, van Petersen AS, Warlé MC. Thromb Res. 2022 Jan;209:106-114. PMID: 34922160 Introduction: Endothelial damage and thrombosis caused by COVID-19 … Continue reading
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ChAdOx1 vaccination, blood coagulation, and inflammation: No effect on coagulation but increased interleukin-6.
Willems LH, Nagy M, Ten Cate H, Spronk HMH, Jacobs LMC, Kranendonk J, van Leeuwen M, Meijer D, Middeldorp S, Groh LA, Warlé MC. Res Pract Thromb Haemost. 2021 Dec 7;5(8):e12630. PMID: 34934894 Background: Vaccination is the leading approach in … Continue reading
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Thrombin generation by calibrated automated thrombography in goat plasma: Optimization of an assay.
D’Alessandro E, Scaf B, van Oerle R, van Nieuwenhoven FA, van Hunnik A, Verheule S, Schotten U, Ten Cate H, Spronk HMH. Res Pract Thromb Haemost. 2021 Nov 21;5(8):e12620. PMID: 34849448 The goat model of atrial fibrillation (AF) allows investigation … Continue reading
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Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1.
D’Alessandro E, Scaf B, Munts C, van Hunnik A, Trevelyan CJ, Verheule S, Spronk HMH, Turner NA, Ten Cate H, Schotten U, van Nieuwenhoven FA. Cells. 2021 Oct 30;10(11):2958. PMID: 34831181 Coagulation factor (F) Xa induces proinflammatory responses through activation of … Continue reading
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Calibrated automated thrombogram II: removing barriers for thrombin generation measurements
P L A Giesen, A J W Gulpen, R van Oerle, H Ten Cate, M Nagy, H M H SpronkThromb J. 2021 Aug 28;19(1):60.PMID: 34454531 Background: Thrombin generation (TG) assessed by Calibrated Automated Thrombogram (CAT-I) reflects the overall capacity of … Continue reading
The impact of platelet indices on clinical outcome in heart failure: results from the MyoVasc study
Bianca Dahlen, Andreas Schulz, Sebastian Göbel, Sven-Oliver Tröbs, Sören Schwuchow-Thonke, Henri M Spronk, Jürgen H Prochaska, Natalie Arnold, Karl J Lackner, Tommaso Gori, Hugo Ten Cate, Thomas Münzel, Philipp S Wild, Marina Panova-NoevaESC Heart Fail. 2021 Aug;8(4):2991-3001.PMID: 33939298 Aims: Platelet … Continue reading
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Tagged heart failure, mean platelet volume, platelet count
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